Description
Lutalyse Injection
Reproductive Management Support for Horses, Cattle, and Swine
Lutalyse is a ready-to-use prostaglandin injection made with dinoprost tromethamine, a naturally occurring prostaglandin used in livestock and equine reproduction programs. It is widely used for estrus synchronization, heat detection support, parturition induction in swine, and controlling the timing of estrus in mares. Each mL contains the equivalent of 5 mg dinoprost, and the product is supplied in 30 mL and 100 mL bottles.
If you are building a complete breeding, reproductive, or horse health program, you can explore more options in our horse care collection or browse related products in the shop.
What Is Lutalyse Used For?
Lutalyse® is indicated for different reproductive uses depending on species.
In Cattle
Lutalyse is used for:
- estrus synchronization in beef and dairy cattle
- treatment of unobserved or silent estrus
- treatment of pyometra (chronic endometritis)
- certain abortion protocols in non-lactating cattle
- use in specific synchronization protocols with FACTREL® and EAZI-BREED™ CIDR® inserts in labeled cattle programs
In Swine
Lutalyse® is indicated for parturition induction in swine, typically when administered within 3 days of the normal predicted farrowing date. The average interval from administration to parturition is approximately 30 hours.
In Mares
For horses, Lutalyse® is indicated for:
- controlling the timing of estrus in estrous cycling mares
- managing clinically anestrous mares that have a corpus luteum
- difficult-to-breed mares where luteolysis is needed to return the mare to estrus
Lutalyse for Horses
What Does Lutalyse Do in Mares?
In mares, Lutalyse® works through its luteolytic effect, which means it helps regress the corpus luteum. As a result, mares that are treated during diestrus commonly return to estrus within 2 to 4 days and typically ovulate 8 to 12 days after treatment. This makes it useful for breeding management and for scheduling stallion use more efficiently.
Lutalyse for Difficult-to-Breed Mares
Some mares that appear anestrous during the breeding season may actually have a functional corpus luteum. In these mares, Lutalyse® may help restart a more usable reproductive cycle by inducing luteolysis and encouraging a return to estrus.
Lutalyse Horse Injection Dose
Basic Mare Dosage
For mares, the labeled dosage is 1 mg per 100 lb body weight, which is usually 1 mL to 2 mL intramuscularly, depending on the mare’s size.
Important Dosing Note
Because Lutalyse® is used across multiple species and reproductive programs, dosage and timing should always be confirmed with your veterinarian. This is especially important when using it in synchronized breeding programs or when pregnancy status is uncertain.
How Long Does Lutalyse Take to Work?
The timing depends on the species and treatment goal:
- Mares: often return to estrus in 2–4 days, with ovulation commonly occurring 8–12 days later
- Swine: parturition may occur about 30 hours after administration when used within the labeled timing window
- Cattle: reproductive response depends on the synchronization program and whether the animal has a responsive corpus luteum
Ingredients and Product Details
Active Ingredient
Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost. The formula also includes benzyl alcohol 16.5 mg as a preservative.
Bottle Sizes
Lutalyse® is commonly supplied in:
- 30 mL
- 100 mL
Storage
Store at controlled room temperature, 20° to 25°C (68° to 77°F), and protect from freezing.
Important Warnings for Lutalyse®
Lutalyse® has important handling warnings and should be used carefully.
Human Safety Warning
This product is not for human use. Women of childbearing age, asthmatics, and people with bronchial or respiratory problems should use extreme caution when handling it. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and/or bronchospasm. Any accidental skin exposure should be washed off immediately with soap and water.
Animal Warnings
- do not administer intravenously
- do not use in pregnant cattle unless abortion is desired
- do not administer to sows or gilts earlier than 3 days before normal predicted farrowing
- in mares, it is ineffective before day 5 after ovulation
- mare pregnancy status should be confirmed before treatment
- mares with acute or subacute disorders of the vascular, gastrointestinal, respiratory, or reproductive systems should not be treated
Residue Information
For labeled uses, there is no milk discard or preslaughter withdrawal period required in cattle, and no preslaughter withdrawal period required in swine. Horses treated with this product should not be used for human consumption.
FAQ’s
What is the purpose of Lutalyse?
Lutalyse® is used for reproductive management, including estrus synchronization, silent estrus treatment, pyometra treatment in cattle, parturition induction in swine, and estrus timing control in mares.
What happens if you give Lutalyse to a pregnant cow?
Lutalyse® is labeled for abortion in certain cattle programs, and pregnant cattle should not be treated unless abortion is desired.
Can you buy Lutalyse over the counter?
No. Federal law in the U.S. restricts this drug to use by or on the order of a licensed veterinarian.
What is another name for Lutalyse?
Lutalyse® is a dinoprost tromethamine injection, which is a prostaglandin F2alpha product.
Where do you inject Lutalyse?
Lutalyse® is for intramuscular use according to labeled directions.
What will Lutalyse do to a human?
It can be dangerous. Dinoprost tromethamine can be absorbed through the skin and may cause abortion or bronchospasm in humans.
Safety and Compliance
This product may expose you to chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm. For more information, please visit P65 Warnings.
Reviews
There are no reviews yet.