Description

ZACTRAN Injectable Solution

ZACTRAN (tildipirosin) is a long‑acting macrolide antibiotic specifically formulated to prevent and treat bovine respiratory disease complex (BRD). By rapidly distributing to lung tissue and maintaining therapeutic levels for up to 28 days, ZACTRAN® controls key pathogens—Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis.

Find all your calf and herd health essentials in our Equine & Livestock Care shop and explore our full range of health supplements & medications.

Key Benefits & Features of ZACTRAN

• Single‑Dose Convenience: Administer 6 mg/kg SC once—no follow‑up injections required.

• Rapid Lung Penetration: Achieves effective lung concentrations within 1 hour.

• Extended Protection: Maintains therapeutic levels for at least 28 days to control shipping fever.

• Broad‑Spectrum Efficacy: Active against common BRD pathogens and reduces secondary bacterial pneumonias.

• Reduced Stress: Minimizes handling by eliminating multiple dosing.

Zactran Indications & Usage

1. Prevention of BRD: Administer at risk of bovine pasteurellosis in feedlots, dairies, and backgrounding operations.

2. Treatment of BRD: Effective against acute and chronic respiratory infections.

Tip: Use ZACTRAN proactively during stressful events—transport, commingling, or environmental changes—to lower incidence of shipping fever.

Dosage & Administration Of Zactran

• Shake well before use.

• Inject under the skin in front of the shoulder.

• Rotate injection sites if treating multiple animals.

Zactran Pharmacokinetics & Mode of Action

Tildipirosin concentrates in pulmonary epithelial lining fluid, where it disrupts bacterial protein synthesis by binding the 50S ribosomal subunit. Consequently, it exhibits potent, bacteriostatic activity against both Gram‑negative and Gram‑positive BRD pathogens.

Safety & Compliance

• Withdrawal Times: Meat—35 days; Milk—do not use in lactating dairy cattle.

• Contraindications: Do not administer IV. Avoid use in swine or other species.

• Adverse Reactions: Rare injection‑site swelling. Monitor for hypersensitivity.

• Storage: 2 – 25 °C; protect from light.

California Proposition 65 Warning: This product may expose you to chemicals known to the State of California to cause cancer or reproductive harm. See https://www.p65warnings.ca.gov/businesses/new-proposition-65-warnings

Frequently Asked Questions

Q1: Does ZACTRAN® treat foot rot or lameness?
A1: While ZACTRAN® targets BRD pathogens, it has no label indication for foot rot. For foot rot treatment, use approved sulfonamides or oxytetracycline under veterinary guidance.

Q2: How quickly does ZACTRAN® work?
A2: Clinical improvement—reduced fever and respiratory signs—often appears within 24–48 hours thanks to rapid lung distribution.

Q3: Can I use ZACTRAN® in combination with vaccines?
A3: Yes, however schedule vaccination at least 7 days before or after ZACTRAN® to ensure optimal immune response.

Q4: Is ZACTRAN® effective against Mycoplasma bovis?
A4: Yes, tildipirosin demonstrates in‑vitro activity against M. bovis, a common contributor to chronic pneumonia.

Related Products & Resources

• Browse our full lineup of injectable and oral antibiotics in the Equine & Livestock Care shop.

• Discover supportive respiratory supplements and immune boosters in our Horse Care & New Products category.

Pro Tip: Implement a comprehensive herd health plan—combine strategic ZACTRAN® use with proper vaccination, nutrition, and stress minimization to maximize performance and reduce BRD losses.